Review paper

The role of the polyol pathway in diabetes mellitus.

Volume: 45, Issue: 1, Pages: 38 - 40
Published: Jan 1, 1991
Abstract
The mechanism by which hyperglycaemia leads to diabetic complications has not been fully elucidated. Non-enzymatic glycosylation leads to considerable functional and structural alteration of proteins. Hyperglycaemia also induces changes in intracellular metabolites, particularly in the polyol pathway. Aldose reductase inhibitors, which block the polyol pathway, have been shown to prevent complications in animal models, and this provides the...
Paper Details
Title
The role of the polyol pathway in diabetes mellitus.
Published Date
Jan 1, 1991
Journal
Volume
45
Issue
1
Pages
38 - 40
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