Pluripotent Conversion of Muscle Stem Cells Without Reprogramming Factors or Small Molecules
Abstract
Muscle derived stem cells (MDSCs) are multipotent stem cells that can differentiate into several lineages including skeletal muscle precursor cells. Here, we show that MDSCs from myostatin null mice (Mstn (-/-) ) can be readily induced into pluripotent stem cells without using reprogramming factors. Microarray studies revealed a strong upregulation of markers like Leukemia Inhibitory factor (LIF) and Leukemia Inhibitory factor receptor (LIFR) in...
Paper Details
Title
Pluripotent Conversion of Muscle Stem Cells Without Reprogramming Factors or Small Molecules
Published Date
Sep 10, 2015
Volume
12
Issue
1
Pages
73 - 89
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