KRAS mutation in lung metastases from colorectal cancer: prognostic implications

KRAS mutant colorectal cancer ( CRC ) patients develop lung and brain metastases more frequently than KRAS wild‐type ( WT ) counterpart. We retrospectively investigated the prognostic role of KRAS , BRAF , and PIK 3 CA (exon 20) mutations and loss of phosphatase and tensin homolog ( PTEN ) in surgically resected lung metastases. Lung specimens from 75 metastatic CRC ( mCRC ) patients treated with one or more metastasectomies with curative intent...