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A review of sepsis-induced cardiomyopathy

Published on Dec 1, 2015in Journal of intensive care
· DOI :10.1186/s40560-015-0112-5
Ryota Sato3
Estimated H-index: 3
,
Michitaka Nasu3
Estimated H-index: 3
Cite
Abstract
Sepsis-induced cardiomyopathy is a reversible myocardial dysfunction that typically resolves in 7–10 days. It is characterized by left ventricular dilatation and depressed ejection fraction. However, many uncertainties exist regarding the mechanisms, characteristics, and treatments of this condition. Therefore, this review attempts to summarize our current knowledge of sepsis-induced cardiomyopathy.
  • References (67)
  • Citations (50)
Cite
References67
Newest
Published on Oct 1, 2015in Journal of Critical Care2.78
Alberto Zangrillo49
Estimated H-index: 49
(UniSR: Vita-Salute San Raffaele University),
Alessandro Putzu7
Estimated H-index: 7
+ 8 AuthorsLikhvantsev Vv5
Estimated H-index: 5
Abstract Purpose There is controversy about the use of inotropes in the treatment of severe sepsis and septic shock. The objective of this study was to evaluate if levosimendan, as compared with standard inotropic therapy (eg, dobutamine), reduces mortality in septic patients. Materials and Methods BioMedCentral, PubMed, EMBASE, and the Cochrane Central Register were searched for pertinent studies, up to 1st May 2015. Randomized trials on the use of levosimendan in patients with severe sepsis an...
Published on Oct 1, 2015in Critical Care Medicine6.97
Yasir Alhamdi9
Estimated H-index: 9
,
Simon T. Abrams9
Estimated H-index: 9
+ 7 AuthorsCheng Hock Toh27
Estimated H-index: 27
Objective:To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis.Design:Prospective, observational clinical study with in vivo and ex vivo translational laboratory investigations.Setting:General ICU and university research labor
Published on Jun 1, 2015in Intensive Care Medicine18.97
Didier Payen62
Estimated H-index: 62
(French Institute of Health and Medical Research),
Joelle Guilhot6
Estimated H-index: 6
(University of Poitiers)
+ 15 AuthorsMatthieu Jabaudon11
Estimated H-index: 11
Purpose To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections.
Published on Apr 2, 2015in The New England Journal of Medicine70.67
Paul R Mouncey7
Estimated H-index: 7
,
Tiffany M. Osborn25
Estimated H-index: 25
+ 12 AuthorsJulian Bion36
Estimated H-index: 36
Background Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertainty about its effectiveness remains. Methods We conducted a pragmatic randomized trial with an integrated cost-effectiveness analysis in 56 hospitals in England. Patients were randomly assigned to receive either EGDT (a 6-hour resuscitation protocol) or usual care. The primary clinical outco...
Published on Jan 1, 2015in Prague medical report
Michal Pořízka2
Estimated H-index: 2
(First Faculty of Medicine, Charles University in Prague),
Petr Kopecký5
Estimated H-index: 5
(First Faculty of Medicine, Charles University in Prague)
+ 3 AuthorsMartin Balik8
Estimated H-index: 8
(First Faculty of Medicine, Charles University in Prague)
A young patient with streptococcal sepsis due to the phlegmon of his left thigh was admitted to the general intensive care unit. He developed a multi-organ failure and septic cardiomyopathy with subsequent cardiogenic shock. This resulted in hemodynamic instability unresponsive to conservative medical treatment. We report a successful application of veno-arterial extra-corporeal membrane oxygenation, which was used to overcome the period of critically low cardiac output caused by severe septic m...
Published on Sep 1, 2014in in Vivo1.61
Noritomo Fujisaki4
Estimated H-index: 4
(Hyogo College of Medicine),
Azusa Takahashi3
Estimated H-index: 3
+ 6 AuthorsKoji Sakaida5
Estimated H-index: 5
Background: Panton-Valentine leukocidin (PVL) is a cytotoxin that causes leukocyte destruction and lung necrosis. Managing respiratory failure and acute respiratory distress syndrome secondary to PVL-expressing Staphylococcus aureus pneumonia and its associated lung necrosis with mechanical ventilation is challenging. We report a patient with life- threatening PVL-expressing S. aureus-associated pneumonia who was rescued using extracorporeal membrane oxygenation (ECMO). Case Report: We examined ...
Alain Combes47
Estimated H-index: 47
,
Daniel Brodie26
Estimated H-index: 26
+ 20 AuthorsJames D. Fortenberry36
Estimated H-index: 36
The use of extracorporeal membrane oxygenation (ECMO) for severe acute respiratory failure (ARF) in adults is growing rapidly given recent advances in technology, even though there is controversy regarding the evidence justifying its use. Because ECMO is a complex, high-risk, and costly modality, at present it should be conducted in centers with sufficient experience, volume, and expertise to ensure it is used safely. This position paper represents the consensus opinion of an international group...
Published on Jan 1, 2014in The New England Journal of Medicine70.67
Sandra L. Peake22
Estimated H-index: 22
,
Anthony Delaney28
Estimated H-index: 28
+ 8 AuthorsSteven A R Webb41
Estimated H-index: 41
Sandra L. Peake, Anthony Delaney, Michael Bailey, Rinaldo Bellomo, Peter A. Cameron, James Cooper, Alisa M. Higgins, Anna Holdgate, Belinda D. Howe, Steven A.R. Webb, Patricia Williams, The Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the Australian and New Zealand Intensive Care Society ANZICS Clinical Trials Group
Published on Jan 1, 2014in Critical Care6.96
John Papanikolaou8
Estimated H-index: 8
(UTH: University of Thessaly),
Demosthenes Makris23
Estimated H-index: 23
(UTH: University of Thessaly)
+ 3 AuthorsEpaminondas Zakynthinos13
Estimated H-index: 13
(UTH: University of Thessaly)
Introduction Elevated plasma B-type natriuretic peptide (BNP) levels in patients with critical sepsis (severe sepsis and septic shock) may indicate septic cardiomyopathy. However, multiple heterogeneous conditions may also be involved in increased BNP level. In addition, the prognostic value of BNP in sepsis remains debatable. In this study, we sought to discover potential independent determinants of BNP elevation in critical sepsis. The prognostic value of BNP was also evaluated.
Published on Jan 1, 2014in The New England Journal of Medicine70.67
Donald M. Yealy44
Estimated H-index: 44
(University of Pittsburgh),
John A. Kellum90
Estimated H-index: 90
(University of Pittsburgh)
+ 9 AuthorsNathan I. Shapiro51
Estimated H-index: 51
In 31 emergency departments in the United States, we randomly assigned patients with septic shock to one of three groups for 6 hours of resuscitation: protocol-based EGDT; protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions; or usual care. The primary end point was 60-day in-hospital mortality. We tested sequentially whether protocol-based care (EGDT and standard-therapy groups combined) was superior ...
Cited By50
Newest
Published on Sep 1, 2019in Journal of Critical Care2.78
Christoph S. Nabzdyk10
Estimated H-index: 10
(Harvard University),
Etienne J. Couture (Harvard University)+ 2 AuthorsEdward A. Bittner23
Estimated H-index: 23
(Harvard University)
Abstract Sepsis remains a major cause of morbidity and mortality, and sepsis-induced cardiomyopathy (SCM) has been recognized as a relevant complication. In this article, the pathophysiology of SCM and the literature regarding the clinical care with a focus on the use of mechanical circulatory support for the rescue of patients with severe SCM are reviewed. Lastly, a pragmatic approach to the care of this complex patient population is provided using a representative case example.
Published on Jul 16, 2019in Herz0.99
T. Yu (Qingdao University), D. Dong + 3 AuthorsQ. Wang (Qingdao University)
Published on Apr 1, 2019in Canadian Journal of Cardiology5.59
Wei Cheng1
Estimated H-index: 1
(Peking Union Medical College Hospital),
Wei Cheng Mm (Peking Union Medical College Hospital)+ 3 AuthorsNa Cui5
Estimated H-index: 5
(Peking Union Medical College Hospital)
Abstract Background Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication of sepsis. Mammalian target of rapamycin (mTOR) signalling pathway is significantly associated with SIMD in an animal model; however, there have been no clinical studies of the association in humans. Methods We enrolled 88 patients with sepsis who were admitted to the intensive care unit (ICU) between April 2017, and April 2018. Biochemical indexes, hemodynamic parameters, and bedside echocardiogr...
Published on 2019in Pharmacological Reports2.76
Vafa Baradaran Rahimi5
Estimated H-index: 5
(MUMS: Mashhad University of Medical Sciences),
Mohammad Taghi Khammar (MUMS: Mashhad University of Medical Sciences)+ 3 AuthorsVahid Reza Askari6
Estimated H-index: 6
(MUMS: Mashhad University of Medical Sciences)
Abstract Background Sepsis causes organ dysfunctions via elevation of oxidative stress and inflammation. Lipopolysaccharide (LPS) is the major surface molecule of most gram-negative bacteria and routinely used as a sepsis model in investigation studies. Crocin is an active compound of saffron which has different pharmacological properties such as anti-oxidant and anti-inflammatory. In this research, the protective effect of crocin was evaluated against LPS-induced toxicity in the embryonic cardi...
Published on Jun 1, 2019in Current Anesthesiology Reports
Pietro Bertini5
Estimated H-index: 5
,
Fabio Guarracino36
Estimated H-index: 36
Purpose of Review The aim of this review is to analyze the cardiovascular pathophysiology of septic shock. Using visual representations of a left ventricular cycle in the pressure/volume plane, we describe hemodynamic derangement occurring in septic shock and subsequent changes at each step of treatment allowing a rapid understanding of complex alterations.
Published on Jun 1, 2019in Redox biology7.79
Ning Li3
Estimated H-index: 3
,
Heng Zhou12
Estimated H-index: 12
+ 4 AuthorsQizhu Tang
Abstract Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis are involved in the development of sepsis and sepsis-induced cardiomyopathy (SIC). Stimulator of interferon genes (STING) is an indispensable molecule that could regulate inflammation and immune response in multiple diseases. However, the role of STING in cardiovascular disease, especially SIC remains unclear. This study was designed to investigate the potential molecular mechanisms of STING in lipop...
Published on Apr 8, 2019in Journal of International Medical Research1.35
The heart is one of the organs most vulnerable to sepsis. This review describes the general characteristics of sepsis-induced cardiomyopathy and the main pathogenesis of myocardial dysfunction in s...
Published on Apr 1, 2019in Journal of Critical Care2.78
Lex M. van Loon1
Estimated H-index: 1
(UT: University of Twente),
Johannes G. van der Hoeven43
Estimated H-index: 43
(Radboud University Nijmegen),
J. Lemson13
Estimated H-index: 13
(Radboud University Nijmegen)
Abstract The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill pati...
Published on Apr 1, 2019in Acute medicine and surgery
Masaki Fujioka8
Estimated H-index: 8
(Mie University),
Kei Suzuki10
Estimated H-index: 10
(Mie University)
+ 4 AuthorsHiroshi Imai15
Estimated H-index: 15
(Mie University)
Jiaojiao Pang3
Estimated H-index: 3
(SDU: Shandong University),
Yue Zheng (SDU: Shandong University)+ 7 AuthorsYuguo Chen4
Estimated H-index: 4
(SDU: Shandong University)
Sepsis, defined as life-threatening tissue damage and organ dysfunction caused by a dysregulated host response to infection, is a critical disease which imposes global health burden. Sepsis-induced organ dysfunction, including circulatory and cardiac dysfunction, hepatic dysfunction, renal dysfunction, etc., contributes to high mortality and long-term disability of sepsis patients. Altered inflammatory response, ROS and reactive aldehyde stress, mitochondrial dysfunction, and programmed cell dea...
View next paperThe Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)