Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease
Abstract
DNA methylation is one of the major epigenetic mechanisms implicated in regulating cellular development and cell-type-specific gene expression. Here we performed simultaneous genome-wide DNA methylation and gene expression analysis on purified intestinal epithelial cells derived from human fetal gut, healthy pediatric biopsies, and children newly diagnosed with inflammatory bowel disease (IBD). Results were validated using pyrosequencing,...
Paper Details
Title
Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease
Published Date
May 1, 2016
Journal
Volume
9
Issue
3
Pages
647 - 658
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