Simulation optimisation of Treatment Sequences for Rheumatoid arthritis

Using simulated annealing (SA) to inform the economic evaluation of treatment sequences for rheumatoid arthritis (RA). A discrete event simulation (DES) model was built to estimate lifetime costs and Quality Adjusted Life Years (QALYs) of alternative sequences for the treatment of patients with severe RA. Thirteen Disease Modifying Anti-Rheumatic Drugs (DMARDs) can be used sequentially, with a theoretical maximum size of the decision space of...