Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Abstract
DNA double-strand breaks (DSBs) disrupt the continuity of chromosomes and their repair by error-free mechanisms is essential to preserve genome integrity. Microhomology-mediated end joining (MMEJ) is an error-prone repair mechanism that involves alignment of microhomologous sequences internal to the broken ends before joining, and is associated with deletions and insertions that mark the original break site, as well as chromosome translocations....
Paper Details
Title
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Published Date
Nov 1, 2015
Volume
40
Issue
11
Pages
701 - 714
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