A mechanism for the suppression of homologous recombination in G1 cells

Nature64.80
Volume: 528, Issue: 7582, Pages: 422 - 426
Published: Dec 17, 2015
Abstract
DNA repair by homologous recombination is highly suppressed in G1 cells to ensure that mitotic recombination occurs solely between sister chromatids. Although many homologous recombination factors are cell-cycle regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G1 cells is unknown. Here we report that the cell cycle controls the interaction of BRCA1 with PALB2-BRCA2 to constrain BRCA2...
Paper Details
Title
A mechanism for the suppression of homologous recombination in G1 cells
Published Date
Dec 17, 2015
Journal
Volume
528
Issue
7582
Pages
422 - 426
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