Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells
Abstract
Non-human primates provide optimal models for the development of stem cell therapies. Although somatic cells have been converted into neural stem/progenitor cells, it is unclear whether telencephalic neuroepithelial stem cells (NESCs) with stable properties can be generated from fibroblasts in primate. Here we report that a combination of transcription factors (Oct4, Sox2, Klf4) with a new culture medium induces rhesus monkey fibroblasts into...
Paper Details
Title
Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells
Published Date
Jan 1, 2016
Journal
Volume
77
Pages
53 - 65
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