Structure of the voltage-gated calcium channel Ca v 1.1 complex
Abstract
The voltage-gated calcium channel Ca(v)1.1 is engaged in the excitation-contraction coupling of skeletal muscles. The Ca(v)1.1 complex consists of the pore-forming subunit α1 and auxiliary subunits α2δ, β, and γ. We report the structure of the rabbit Ca(v)1.1 complex determined by single-particle cryo-electron microscopy. The four homologous repeats of the α1 subunit are arranged clockwise in the extracellular view. The γ subunit, whose...
Paper Details
Title
Structure of the voltage-gated calcium channel Ca v 1.1 complex
Published Date
Dec 18, 2015
Journal
Volume
350
Issue
6267
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