Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice
Abstract
Sperm-egg fusion is indispensable for completing mammalian fertilization. Although the underlying molecular mechanisms are poorly understood, requirement of two spermatozoon factors, IZUMO1 and SPACA6, and two oocyte factors, CD9 and the IZUMO1 counter-receptor JUNO, has been proven by gene disruption, and the binding of cells to an oocyte can be reconstituted by ectopic expression of IZUMO1. Here we demonstrate that robust IZUMO1-dependent...
Paper Details
Title
Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice
Published Date
Nov 16, 2015
Journal
Volume
6
Issue
1
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