Match!

The dopamine D1 receptor agonist SKF-82958 effectively increases eye blinking count in common marmosets

Published on Mar 1, 2016in Behavioural Brain Research2.77
· DOI :10.1016/j.bbr.2015.11.028
Manato Kotani4
Estimated H-index: 4
,
Akihiko Kiyoshi4
Estimated H-index: 4
+ 6 AuthorsKazuhito Ikeda6
Estimated H-index: 6
View in Source
Abstract
Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson’s disease and Tourette syndrome [1] ;  [2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field due to their more developed prefrontal cortex than rodents, easy handling compare to other non-human primates, and requirement for small amounts of test drugs. In this study, we evaluated the effects of dopamine D1–4 receptors agonists on eye blinking in common marmosets. Our results show that the dopamine D1 receptor agonist SKF-82958 and the non-selective dopamine receptor agonist apomorphine significantly increased common marmosets eye blinking count, whereas the dopamine D2 agonist (+)-PHNO and the dopamine D3 receptor agonist (+)-PD-128907 produced somnolence in common marmosets resulting in a decrease in eye blinking count. The dopamine D4 receptor agonists PD-168077 and A-41297 had no effect on common marmosets’ eye blinking count. Finally, the dopamine D1 receptor antagonist SCH 39166 completely blocked apomorphine-induced increase in eye blinking count. These results indicate that eye blinking in common marmosets may be a useful tool for in vivo screening of novel dopamine D1 receptor agonists as antipsychotics.
  • References (45)
  • Citations (11)
References45
Newest
#1Tomokazu NakakoH-Index: 7
#2Takeshi MuraiH-Index: 5
Last.Kazuhito IkedaH-Index: 6
view all 11 authors...
5 CitationsSource
#1Aristea Ladas (University of Sheffield)H-Index: 3
#2Christos A. Frantzidis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 16
Last.Ana B. Vivas (University of Sheffield)H-Index: 21
view all 4 authors...
22 CitationsSource
#1Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
#2Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
Last.Mutsuo Taiji (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 24
view all 6 authors...
19 CitationsSource
#1Donald L. Gilbert (Cincinnati Children's Hospital Medical Center)H-Index: 42
#2Cathy L. Budman (North Shore-LIJ Health System)H-Index: 27
Last.Richard E. ChipkinH-Index: 3
view all 5 authors...
49 CitationsSource
#1Noriyuki Kishi (Keio: Keio University)H-Index: 11
#2Kenya Sato (Central Institute for Experimental Animals)H-Index: 3
Last.Hideyuki Okano (Keio: Keio University)H-Index: 112
view all 4 authors...
99 CitationsSource
#1Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
#2Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
Last.Kazuhito Ikeda (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 6
view all 6 authors...
18 CitationsSource
#1Mirko Manchia (Dal: Dalhousie University)H-Index: 21
#2Mazda Adli (Charité)H-Index: 32
Last.Martin Alda (Dal: Dalhousie University)H-Index: 57
view all 100 authors...
245 CitationsSource
#1Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
#2Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
Last.Kazuhito Ikeda (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 6
view all 6 authors...
14 CitationsSource
#1Hideoki Tada (Tohoku Gakuin University)H-Index: 4
#2Yasuko Omori (Jin-ai University)H-Index: 3
Last.Masaki Tomonaga (Primate Research Institute)H-Index: 29
view all 5 authors...
19 CitationsSource
#1Jonathan Melamed (RMIT: RMIT University)H-Index: 52
#2Maria A. de Souza Silva (HHU: University of Düsseldorf)H-Index: 28
Last.Marilia Barros (RMIT: RMIT University)H-Index: 17
view all 6 authors...
6 CitationsSource
Cited By11
Newest
#1Donald L. Gilbert (Cincinnati Children's Hospital Medical Center)H-Index: 42
#2Tanya K. Murphy (USF: University of South Florida)H-Index: 52
Last.Richard E. ChipkinH-Index: 3
view all 11 authors...
4 CitationsSource
#1Guillaume Sescousse (Radboud University Nijmegen)H-Index: 14
#2Romain Ligneul (Radboud University Nijmegen)H-Index: 1
Last.Roshan Cools (Radboud University Nijmegen)H-Index: 51
view all 9 authors...
13 CitationsSource
#1Dharmendra Gurve (RyeU: Ryerson University)H-Index: 1
#2Sridhar Krishnan (RyeU: Ryerson University)H-Index: 31
2 CitationsSource
#1As Lee (SBU: Stony Brook University)
#2Bk Blankson (SBU: Stony Brook University)
Last.Hoi-Chung Leung (SBU: Stony Brook University)H-Index: 27
view all 6 authors...
Source
#1Linh C. Dang (Vandy: Vanderbilt University)H-Index: 11
#2Gregory R. Samanez-Larkin (Duke University)H-Index: 25
Last.David H. Zald (Vandy: Vanderbilt University)H-Index: 56
view all 7 authors...
14 CitationsSource
#1Ki-Wan KimH-Index: 1
#2Hyung Gil HongH-Index: 9
Last.P Kang RyoungH-Index: 34
view all 4 authors...
15 CitationsSource
#1Manato KotaniH-Index: 4
#2Naoko UrushinoH-Index: 1
Last.Kazuhito IkedaH-Index: 6
view all 5 authors...
4 CitationsSource
#1Maria K. Eckstein (University of California, Berkeley)H-Index: 2
#2Belén Guerra-Carrillo (University of California, Berkeley)H-Index: 3
Last.Silvia A. Bunge (University of California, Berkeley)H-Index: 47
view all 4 authors...
85 CitationsSource
#1Bryant J. Jongkees (LEI: Leiden University)H-Index: 6
#2Lorenza S. Colzato (LEI: Leiden University)H-Index: 40
50 CitationsSource
#1Manato KotaniH-Index: 4
#2Takeshi EnomotoH-Index: 7
Last.Kazuhito IkedaH-Index: 6
view all 12 authors...
4 CitationsSource