Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities
Abstract
Exonuclease 1 (Exo1) has important roles in DNA metabolic transactions that are essential for genome maintenance, telomere regulation and cancer suppression. However, the mechanisms for regulating Exo1 activity in these processes remain incompletely understood. Here, we report that Exo1 activity is regulated by a direct interaction with poly(ADP-ribose) (PAR), a prominent posttranslational modification at the sites of DNA damage. This...
Paper Details
Title
Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities
Published Date
Nov 1, 2015
Journal
Volume
35
Pages
106 - 115
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