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Palladium(II) complexes with tris(2-carboxyethyl)phosphine, structure, reactions and cytostatic activity

Published on Mar 1, 2016in Journal of Inorganic Biochemistry3.22
· DOI :10.1016/j.jinorgbio.2015.12.001
Hanna Pruchnik10
Estimated H-index: 10
(Wroclaw University of Environmental and Life Sciences),
Tadeusz Lis30
Estimated H-index: 30
(UWr: University of Wrocław)
+ 2 AuthorsFlorian P. Pruchnik18
Estimated H-index: 18
(UWr: University of Wrocław)
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Abstract
Abstract Water soluble and air stable P(RCOOH) 3 (R = C 2 H 4 ) (TCEP) is an efficient reducing agent used in biochemistry to break S–S bond in peptides, proteins and other compounds containing S–S bonds. The similarity between the coordination chemistry of Pd(II) and Pt(II) led to the investigations of antitumor activity of palladium(II) compounds however the Pd(II) complexes with TCEP were not investigated. New palladium(II) complexes with (TCEP): trans -[PdCl 2 (TCEP) 2 ] ( 1 ) and trans -[Pd 2 ( μ -Cl) 2 Cl 2 (TCEP) 2 ] ( 2 ) were fully characterized by 1 H, 13 C, 31 P NMR, IR and ESI-MS spectroscopic techniques. Complexes are stable in non-aqueous DMSO and DMF. In aqueous solutions Cl ligands are substituted by COO groups of phosphines. Complex 2 , after crystallization from water gives polymeric compound with bridging phosphine ligand [PdCl{P(RCOO- κO - μ - O ′)(RCOOH) 2 - κP }] ( 3 ). Structures of trans -[PdCl 2 {P(RCOOD) 3 } 2 ] ( 1a ), trans -[Pd 2 ( μ -Cl) 2 PdCl 2 {P(RCOOD) 3 } 2 ] ( 2a ), and [PdCl{P(RCOO -κO - μ - O ′)(RCOOD) 2 - κP }] n ( 3a ) have been determined by X-ray crystallography. NMR and ESI-MS spectra reveal that [PdP 2 (RCOO- κO ) 2 (RCOO) n (RCOOH) 4 − n ] n – complexes are formed in aqueous solution of 1 . Geometry optimization in the gas phase at the B3LYP/3-21G** level indicated that complex 2 with butterfly structure is more stable than that with coplanar coordination. In aqueous solution of 2 , the main products [Pd 2 {P(RCOO -κO - μ - O ′)(RCOO- κO )(RCOOH)} 2 ] and [Pd{P(RCOO- κO ) 2 (RCOOH)}(H 2 O)] exist in equilibrium which depends on temperature: content of mononuclear compound increases as the temperature is raised. Complexes 1 and 2 are active agents against melanoma and breast cancer cells.
  • References (36)
  • Citations (6)
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References36
Newest
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Tadeusz Lis (UWr: University of Wrocław)H-Index: 30
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 18
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#1William M. Motswainyana (UWC: University of the Western Cape)H-Index: 6
#2Martin O. Onani (UWC: University of the Western Cape)H-Index: 9
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#1M.L. Mena (Complutense University of Madrid)H-Index: 12
#2Estefanía Moreno-Gordaliza (Complutense University of Madrid)H-Index: 11
Last.M. Milagros Gómez-Gómez (Complutense University of Madrid)H-Index: 14
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#1Natalia Cutillas (University of Murcia)H-Index: 15
#2Gorakh S. Yellol (University of Murcia)H-Index: 8
Last.José Ruiz (University of Murcia)H-Index: 32
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#1Kazem Karami (IUT: Isfahan University of Technology)H-Index: 16
#2Mahboubeh Hosseini Kharat (IUT: Isfahan University of Technology)H-Index: 2
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#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Małgorzata Latocha (Medical University of Silesia)H-Index: 12
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 18
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#1Siming Chen (USTC: University of Science and Technology of China)H-Index: 6
#2Huan Jiang (USTC: University of Science and Technology of China)H-Index: 2
Last.Yangzhong Liu (USTC: University of Science and Technology of China)H-Index: 19
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#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Tadeusz Lis (UWr: University of Wrocław)H-Index: 30
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 18
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#1Martin Vojtek (University of Porto)H-Index: 1
#2M. P. M. Marques (UC: University of Coimbra)H-Index: 22
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#2Keith B. Dillon (Durham University)H-Index: 15
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#1Sourav Bhowmick (IITP: Indian Institute of Technology Patna)H-Index: 6
#2Achintya Jana (IITP: Indian Institute of Technology Patna)H-Index: 4
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#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Małgorzata Latocha (Medical University of Silesia)H-Index: 12
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 18
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#1Yan Zheng (SDU: Shandong University)H-Index: 5
#2Liying Fang (SDU: Shandong University)H-Index: 1
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