Palladium(II) complexes with tris(2-carboxyethyl)phosphine, structure, reactions and cytostatic activity

Water soluble and air stable P(RCOOH)3 (R = C2H4) (TCEP) is an efficient reducing agent used in biochemistry to break S–S bond in peptides, proteins and other compounds containing S–S bonds. The similarity between the coordination chemistry of Pd(II) and Pt(II) led to the investigations of antitumor activity of palladium(II) compounds however the Pd(II) complexes with TCEP were not investigated. New palladium(II) complexes with (TCEP):...