Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
Volume: 1863, Issue: 7, Pages: 1728 - 1748
Published: Jul 1, 2016
Abstract
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in hPSC isolation, Cas9/CRISPR genome engineering and hPSC-CM differentiation have improved patient care, progressed drugs to clinic and opened a new era in safety pharmacology. Nevertheless, predictive cardiotoxicity...
Paper Details
Title
Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
Published Date
Jul 1, 2016
Volume
1863
Issue
7
Pages
1728 - 1748
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