Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures
Abstract
Diverse repertoires of antigen-receptor genes that result from combinatorial splicing of coding segments by V(D)J recombination are hallmarks of vertebrate immunity. The (RAG1-RAG2)2 recombinase (RAG) recognizes recombination signal sequences (RSSs) containing a heptamer, a spacer of 12 or 23 base pairs, and a nonamer (12-RSS or 23-RSS) and introduces precise breaks at RSS-coding segment junctions. RAG forms synaptic complexes only with one...
Paper Details
Title
Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures
Published Date
Nov 1, 2015
Journal
Volume
163
Issue
5
Pages
1138 - 1152
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