Sequential Notch activation regulates ventricular chamber development
Abstract
Ventricular chambers are essential for the rhythmic contraction and relaxation occurring in every heartbeat throughout life. Congenital abnormalities in ventricular chamber formation cause severe human heart defects. How the early trabecular meshwork of myocardial fibres forms and subsequently develops into mature chambers is poorly understood. We show that Notch signalling first connects chamber endocardium and myocardium to sustain...
Paper Details
Title
Sequential Notch activation regulates ventricular chamber development
Published Date
Dec 7, 2015
Journal
Volume
18
Issue
1
Pages
7 - 20
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