Match!

Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport.

Published on Jul 1, 2001in Journal of Lipid Research4.74
L. J. Schurgers1
Estimated H-index: 1
,
C. Vermeer1
Estimated H-index: 1
Abstract
In this article we report the effects of low and high fat diets on the arterial thrombosis tendency in rats. The animal system used was the aorta loop model, in which we compared the effect of saturated (hardened coconut oil, HCO) and unsaturated (sunflower seed oil, SSO; corn oil, CO) fatty acids on the arterial thrombosis tendency at high fat intake (50 energy%, 45 energy% of which was either HCO, SSO, or CO). Under these conditions both SSO and CO had a beneficial effect (relative to HCO) on the arterial thrombosis tendency. In a subsequent study we compared these high fat diets with a low fat diet (5 energy%). As com- pared with the low fat diet, only CO significantly decreased the thrombosis risk. Serum vitamin K and triglycerides had decreased substantially after the CO diet, and to a much lesser extent after the SSO diet. It is concluded that corn oil may have a mildly anticoagulant effect, the potential benefit of which is discussed. —Schurgers, L. J., and C. Ver- meer. Corn oil-induced decrease in arterial thrombosis ten- dency may be related to altered plasma vitamin K transport. J. Lipid Res. 2001. 42: 1120-1124.
  • References (34)
  • Citations (6)
References34
Newest
Published on Dec 3, 2009in Journal of Bone and Mineral Research5.71
Pawel Szulc39
Estimated H-index: 39
(French Institute of Health and Medical Research),
M. Arlot45
Estimated H-index: 45
(French Institute of Health and Medical Research)
+ 3 AuthorsPierre D. Delmas135
Estimated H-index: 135
(French Institute of Health and Medical Research)
We previously showed that circulating undercarboxylated osteocalcin (ucOC) is elevated in elderly women and is a powerful marker of the subsequent risk of hip fracture in elderly institutionalized women (J Clin Invest 1993; 91:1769). To investigate the relationship between bone mass and ucOC, we measured bone mineral density (BMD) of the hip with dual-energy x-ray absorptiometry in 98 elderly institutionalized women, 81.4 + 6.0 years old. ucOC was negatively correlated with BMD at all sites (r =...
Published on Dec 3, 2009in Journal of Bone and Mineral Research5.71
James R. Ketudat Cairns20
Estimated H-index: 20
(UCSD: University of California, San Diego),
Paul A. Price81
Estimated H-index: 81
(UCSD: University of California, San Diego)
Incomplete vitamin K-dependent γ-carboxylation has been found in bone Gla protein (BGP) isolated from each of 20 different human bone samples. Using N-terminal protein sequencing of the methyl-esterified protein (Anal Biochem 1991;199:93-97), a method that directly measures the percentage of γ-carboxylation at each target glutamate residue, the extent of incomplete BGP γ-carboxylation was found to depend strongly on sequence position, with (x + SD) 67 + 14% γ-carboxylation at residue 17, 88 + 9%...
Published on Jan 1, 1995
R Charles Scriver1
Estimated H-index: 1
I. INTRODUCTION II. PERSPECTIVES III. GENERAL THEMES IV. CANCER V. CHROMOSOMES VI. DIAGNOSTIC APPROACHES VII. CARBOHYDRATES VIII. AMINO ACIDS IX. ORGANIC ACIDS X. DISORDERS OF MITOCHONDRIAL FUNCTION XI. PURINES AND PYRIMIDINES XII. LIPIDS XIII. PORPHYRINS XIV. METALS XV. PEROXISOMES XVI. LYSOSOMAL DISORDERS XVII. VITAMINS XVIII. HORMONES XIX. BLOOD XX. IMMUNE AND DEFENSE SYSTEMS XXI. MEMBRANE TRANSPORT DISORDERS XXII. CONNECTIVE TISSUE XXIII. CARDIOVASCULAR SYSTEM XXIV. KIDNEY XXV. MUSCLE XXVI. ...
Published on Nov 1, 1998in Calcified Tissue International3.27
Marjo H. J. Knapen23
Estimated H-index: 23
(UM: Maastricht University),
A. C. Nieuwenhuijzen Kruseman13
Estimated H-index: 13
(UM: Maastricht University)
+ 1 AuthorsCees Vermeer58
Estimated H-index: 58
(UM: Maastricht University)
Serum immunoreactive osteocalcin (irOC) consists of two fractions that differ from each other by their affinity for hydroxyapatite. The high and low affinity fractions are referred to as irOCbound and irOCfree, respectively. To evaluate whether these fractions are determinants for different characteristics of bone or bone metabolism, we have performed a cross-sectional study among 212 apparently healthy women between 20 and 90 years of age. Bone mineral density (BMD) was determined at the lumbar...
Published on Sep 1, 1998in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Cécile M.A. Nieuwenhuys6
Estimated H-index: 6
(UM: Maastricht University),
Suzette Béguin34
Estimated H-index: 34
(UM: Maastricht University)
+ 3 AuthorsJohan W. M. Heemskerk54
Estimated H-index: 54
(UM: Maastricht University)
We investigated the effects of dietary polyunsaturated fatty acids (PUFAs) on blood lipids and processes that determine hemostatic potential: platelet activation, coagulation, and fibrinolysis. For 8 to 10 weeks, Wistar rats were fed a high-fat diet containing various amounts (2% to 16%) of n-3 PUFAs derived from fish oil (FO) or a diet enriched in n-6 PUFAs from sunflower seed oil (SO). Only the FO diets caused a reduction in mean platelet volume, platelet arachidonate level, and formation of t...
Published on Sep 1, 1998in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Paul A. Price81
Estimated H-index: 81
(UCSD: University of California, San Diego),
Samuel A. Faus3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Matthew K. Williamson25
Estimated H-index: 25
(UCSD: University of California, San Diego)
Abstract —High doses of warfarin cause focal calcification of the elastic lamellae in the media of major arteries and in aortic heart valves in the rat. Aortic calcification was first seen after 2 weeks of warfarin treatment and progressively increased in density at 3, 4, and 5 weeks of treatment. By 5 weeks, the highly focal calcification of major arteries could be seen on radiographs and by visual inspection of the artery. The calcification of arteries induced by warfarin is similar to that se...
Published on Jun 1, 1998in The American Journal of Clinical Nutrition6.57
Stefania Lamon-Fava39
Estimated H-index: 39
(USDA: United States Department of Agriculture),
James A. Sadowski35
Estimated H-index: 35
(USDA: United States Department of Agriculture)
+ 3 AuthorsErnst J. Schaefer117
Estimated H-index: 117
(USDA: United States Department of Agriculture)
The purpose of this study was to characterize the absorption and transport of phylloquinone (vitamin K 1 ) by plasma lipoproteins. Twenty-six healthy subjects (11 men and 15 women) aged 20-78 y received phylloquinone in the amount of either 1.43 or 50 μg/kg body wt orally with a fat-rich meal containing 1.0 g/kg body wt of fat, carbohydrate, and protein and 7.0 mg cholesterol/kg body wt. Blood was obtained at baseline (0 h) and 3, 6, 9, and 12 h after the meal for the measurement of plasma lipid...
Published on May 1, 1997in Atherosclerosis4.25
Gerard Hornstra43
Estimated H-index: 43
(UM: Maastricht University),
Arnold D. M. Kester54
Estimated H-index: 54
(UM: Maastricht University)
To study the influence of dietary fatty acids on arterial thrombosis tendency 65 groups of male rats were fed diets containing 50% of their digestible energy as fat from 32 different oils and fats. After 8 weeks their arterial thrombosis tendency was assessed by measuring the obstruction time (OT) of a loop-shaped polythene cannula inserted into the abdominal aorta. Using multiple regression analysis log10 OT was modelled as a function of the relative amounts of the various dietary fatty acids a...
Published on Nov 1, 1996in Biochimica et Biophysica Acta3.79
Jacintha E. Ronden6
Estimated H-index: 6
,
B.A.M. Soute20
Estimated H-index: 20
+ 2 AuthorsCees Vermeer58
Estimated H-index: 58
Abstract Vitamin K belongs to a class of compounds commonly known as prenylquinones. Three other prenylquinones which are abundantly found in food are plastoquinone-9, ubiquinone-9 and ubiquinone-10. Using in vitro assay systems, it was recently found that synthetic derivatives of prenylquinones inhibit the vitamin K-dependent enzyme γ-glutamylcarboxylase and, to a lesser extent, the vitamin K-epoxide reductase. In this paper we describe how natural prenylquinones affect the vitamin K-dependent ...
Cited By6
Newest
Published on Jan 1, 2016
Introduction: Treatments of retinoic acid, a metabolite of vitamin A (VA) are shown to induce hyperlipidemia in humans and animals, which may influence adiposity. To understand the role of VA in weight management, two studies, one in animals examining effects of VA combined with high-fat diet (HFD) on body mass (BM) gain and the second in humans comparing dietary VA between participants who were overweight/obese and who had and had not lost 10% of body weight by consuming a hypocaloric, low-fat ...
Published on Jan 1, 2015
Jennifer Eastep1
Estimated H-index: 1
,
Guoxun Chen17
Estimated H-index: 17
Obesity has become a worldwide problem. One dietary style contributing to this epidemic is the Western diet or high-fat diet (HFD), which is marked by its high-fat content. The effects of HFD on the development of chronic metabolic diseases, such as obesity, have been observed in both human and animal studies. Consumption of HFD generally causes increase of body fat mass with development of symptoms of metabolic diseases such as hyperlipidemia and insulin resistance. Micronutrients are essential...
Published on Oct 1, 2011in British Journal of Nutrition3.32
Francesca Brugè13
Estimated H-index: 13
,
Tiziana Bacchetti25
Estimated H-index: 25
+ 2 AuthorsLuca Tiano17
Estimated H-index: 17
Menaquinone-7 (MK-7), a member of the vitamin K 2 family, performs several functions, all related to its recognised effect on post-translational carboxylation of certain protein-bound glutamate residues. Due to its lipophilic structure MK-7 is soluble in olive oil, so the aim of the present study was to test whether extra-virgin (EV) olive oil enriched with MK-7 significantly increases MK-7 plasma levels and has an effect on osteocalcin and its carboxylation status. Healthy young volunteers ( n ...
Published on Aug 1, 2009in Canadian Journal of Physiology and Pharmacology2.04
K. Govindan NevinK.G. Nevin1
Estimated H-index: 1
(UoK: University of Kerala),
Thankappan Rajamohan10
Estimated H-index: 10
(UoK: University of Kerala)
Because coconut oil extracted by wet process (virgin coconut oil, VCO) is gaining popularity among consumers, this study was conducted to evaluate VCO compared with coconut oil extracted by dry process (copra oil, CO) for their influence on lipid parameters, lipid peroxidation, and antioxidant status in rats coadministered with cholesterol. VCO, CO, and cholesterol were fed in a semi-synthetic diet to 24 male Sprague–Dawley rats for 45 days. After the experimental period, lipid and lipid peroxid...
Published on Jan 23, 2007in Bioscience, Biotechnology, and Biochemistry1.30
Hideharu Fukao1
Estimated H-index: 1
(Kurashiki Sakuyo University),
Hideki Yoshida3
Estimated H-index: 3
+ 1 AuthorsTakahiko Hada19
Estimated H-index: 19
Antithrombotic activities of odorless garlic powder were demonstrated in blood fibrinolytic and coagulation systems. Though the odorless garlic preparation did not influence tissue-type plasminogen activator (t-PA) or its inhibitor secretions from human umbilical vein endothelial cells, it enhanced plasmin generation by t-PA on fibrin film and in chromogenic assays by 1.8-fold and 8.7-fold respectively. The coagulation system was considerably reduced after the administration of the garlic in a r...
Published on Sep 1, 2004in Clinical Biochemistry2.43
Kottayath Govindan Nevin3
Estimated H-index: 3
(UoK: University of Kerala),
Thankappan Rajamohan10
Estimated H-index: 10
(UoK: University of Kerala)
Objectives: The present study was conducted to investigate the effect of consumption of virgin coconut oil (VCO) on various lipid parameters in comparison with copra oil (CO). In addition, the preventive effect of polyphenol fraction (PF) from test oils on copper induced oxidation of LDL and carbonyl formation was also studied. Design and methods: After 45 days of oil feeding to Sprague–Dawley rats, several lipid parameters and lipoprotein levels were determined. PF was isolated from the oils an...
View next paperComparison of the uptake and processing of cholesterol from chylomicrons of different fatty acid composition in rats fed high-fat and low-fat diets