Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1

Volume: 488, Pages: 271 - 277
Published: Jan 1, 2016
Abstract
SAMHD1 is a cellular dNTPase that restricts lentiviral infection presumably by lowering cellular dNTP levels to below a critical threshold required for reverse transcription; however, lowering cellular dNTP levels may not be the sole mechanism of restriction. In particular, an exonuclease activity of SAMHD1 was reported to contribute to virus restriction. We further investigated the requirements for SAMHD1 restriction activity in both...
Paper Details
Title
Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1
Published Date
Jan 1, 2016
Journal
Volume
488
Pages
271 - 277
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