Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.

Cell64.50
Volume: 163, Issue: 6, Pages: 1444 - 1456
Published: Dec 3, 2015
Abstract
The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal epithelial cells (Δ/EC) conferred protection from...
Paper Details
Title
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.
Published Date
Dec 3, 2015
Journal
Volume
163
Issue
6
Pages
1444 - 1456
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