High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation
Abstract
Diabetes is an important health issue because of its increasing prevalence and association with impaired wound healing. Epidermal keratinocytes with overexpressed antiangiogenic molecule thrombospondin-1 (TSP1) have been shown to impair proper wound healing. This study examined the potential involvement of keratinocyte-derived TSP1 on diabetic wound healing. Cultured human keratinocytes and diabetic rat model were used to evaluate the effect of...
Paper Details
Title
High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation
Published Date
Mar 1, 2016
Journal
Volume
169
Pages
91 - 101.e3
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