Stability of the Cathelicidin Peptide LL-37 in a Non-healing Wound Environment
Abstract
The endogenous cathelicidin peptide LL-37 is strongly expressed at the wound edge early in the process of acute wound healing, but only weakly expressed in chronic wounds. Excessive proteolysis may limit the therapeutic usefulness of exogenous LL-37, especially in ulcers colonized with Pseudomonas aeruginosa that produce elastase, which degrades LL-37. This study investigated the stability of synthetic LL-37 against two types of proteinases in...
Paper Details
Title
Stability of the Cathelicidin Peptide LL-37 in a Non-healing Wound Environment
Published Date
Jan 1, 2011
Journal
Volume
91
Issue
5
Pages
511 - 515
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