Original paper
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
Abstract
Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the bioinformatics tools 'expanding ploidy and allele frequency on nested subpopulations' (EXPANDS) and PyClone to detect clones that are present at a ≥10% frequency in 1,165 exome sequences from tumors in The Cancer Genome Atlas. 86% of tumors across 12 cancer types had at least two clones. ITH in the morphology of nuclei was associated with genetic...
Paper Details
Title
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
Published Date
Nov 30, 2015
Journal
Volume
22
Issue
1
Pages
105 - 113
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Notes
History