A perspective on NETosis in diabetes and cardiometabolic disorders

To review the significance of a new type of neutrophil cell death (NETosis) in diabetes and cardiometabolic diseases.Diabetes and the metabolic syndrome are characterized by activation of the innate immune system. In this framework, neutrophils are front line defences against infections, but can also turn deleterious if abnormally stimulated. NETosis refers to a type of cell death whereby neutrophils release nuclear material and granule enzymes...