Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Abstract
Adipose tissue plays important roles in regulating carbohydrate and lipid homeostasis, but less is known about the regulation of amino acid metabolism in adipocytes. Here we applied isotope tracing to pre-adipocytes and differentiated adipocytes to quantify the contributions of different substrates to tricarboxylic acid (TCA) metabolism and lipogenesis. In contrast to proliferating cells, which use glucose and glutamine for acetyl-coenzyme A...
Paper Details
Title
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Published Date
Nov 16, 2015
Journal
Volume
12
Issue
1
Pages
15 - 21
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