Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain
Abstract
Failure to close the neural tube results in birth defects, with severity ranging from spina bifida to lethal anencephaly. Few genetic risk factors for neural tube defects are known in humans, highlighting the critical role of environmental risk factors, such as maternal diabetes. Yet, it is not well understood how altered maternal metabolism interferes with embryonic development and with neurulation in particular. We present evidence from two...
Paper Details
Title
Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain
Published Date
Nov 23, 2015
Journal
Volume
5
Issue
1
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