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VACCINATION OF CHICKS WITH LIVE ATTENUATED SUBTYPE B AVIAN METAPNEUMOVIRUS VACCINES: PROTECTION AGAINST CHALLENGE AND IMMUNE RESPONSES CAN BE UNRELATED TO VACCINE DOSE

Published on Sep 1, 2007in Avian Diseases1.31
· DOI :10.1637/0005-2086(2007)51[733:VOCWLA]2.0.CO;2
Kannan Ganapathy12
Estimated H-index: 12
,
R. C. Jones35
Estimated H-index: 35
Cite
Abstract
Abstract Live attenuated subtype B avian metapneumovirus (aMPV) vaccines from two different commercial sources (Vac 1 and Vac 2) were used to vaccinate two groups of day-old specific-pathogen-free chicks. The chicks were challenged at 21 or 49 days of age with a virulent subtype B virus. Parameters compared were persistence of vaccine viruses, their ability to induce humoral antibody responses, and the protection they offered against virulent challenge. Vac 1 virus was detectable for at least 14 days after vaccination, and Vac 2 virus was detectable for at least 7 days after vaccination. The serologic response after Vac 1 by using a subtype B-based enzyme-linked immunosorbent assay was significantly higher than that induced by Vac 2, even though the titer of the recommended dose had a higher titer than Vac 1. After challenge at 21 or 49 days of age, both vaccines gave 100% protection against clinical disease. For the recovery of challenge virus, one of 10 chicks given the Vac 2 was positive by virus isola...
  • References (17)
  • Citations (9)
Cite
References17
Newest
Published on Jan 1, 2006in Journal of Veterinary Medical Science0.91
Miki Sugiyama2
Estimated H-index: 2
(Merial),
Hiroyuki Koimaru1
Estimated H-index: 1
(Merial)
+ 3 AuthorsToshihiro Ito25
Estimated H-index: 25
(Tottori University)
Decreases in egg production and increased incidence of abnormal eggs due to malformation of egg shells were observed in specific pathogen free (SPF) 173-day-old laying hens inoculated intravenously with an avian metapneumovirus (aMPV) strain PLE8T1. This strain was derived from an isolate from broiler birds exhibiting swollen head syndrome (SHS). Some SPF birds inoculated with the virus showed, slight diarrhea without any respiratory symptoms. Thus, the PLE8T1 strain was used as a challenge viru...
Published on Aug 1, 2005in Avian Pathology1.96
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool),
P. Cargill4
Estimated H-index: 4
(Merial)
+ 1 AuthorsR. C. Jones35
Estimated H-index: 35
(University of Liverpool)
One-day-old specific pathogen free White Leghorn chicks were vaccinated with live avian pneumovirus (APV) vaccine, live Newcastle disease virus (NDV) vaccine or both. At intervals up to 28 days after vaccination, distribution of the virus in the tissues was studied, together with humoral and mucosal antibody responses in lachrymal fluid and tracheal washes. APV vaccine was detected for almost twice as long in the dual vaccinates as in the single vaccinates. Higher numbers of isolations of ND vir...
Published on Feb 1, 2004in Avian Pathology1.96
Michael Hess33
Estimated H-index: 33
,
M.B. Huggins2
Estimated H-index: 2
+ 1 AuthorsU. Heincz2
Estimated H-index: 2
Vaccinated and non-vaccinated specified pathogen-free White Leghorn laying chickens were challenged at peak of lay by the intravenous or oculonasal route with a virulent avian metapneumovirus (aMPV) subtype B chicken strain. Severe clinical signs and a drop in egg production were induced in the non-vaccinated intravenously challenged birds whereas the vaccinates were not affected. Live virus excretion was demonstrated in the faeces and respiratory tract of non-vaccinated hens for up to 7 days po...
Published on Aug 1, 2002in Avian Pathology1.96
Devi P. Patnayak16
Estimated H-index: 16
,
Anwar M. Sheikh4
Estimated H-index: 4
(UMN: University of Minnesota)
+ 1 AuthorsSagar M. Goyal49
Estimated H-index: 49
The attenuation of an avian pneumovirus (APV) isolate (APV/MN/turkey/1-a/97) by 63 serial passages in cell culture (seven in chicken embryo fibroblasts and 56 in Vero cells) and its evaluation as a live attenuated vaccine in turkey poults is described. The birds were vaccinated with two different doses of attenuated virus (10 4.5 median tissue culture infectious dose (TCID 50 )/ml and 10 2.5 TCID 50 /ml) at 2 weeks of age, and were challenged 2 weeks later with virulent APV. No clinical signs we...
Published on Jun 1, 2001in Avian Pathology1.96
Jane K. A. Cook31
Estimated H-index: 31
,
M. B. Huggins18
Estimated H-index: 18
+ 2 AuthorsDavid Cavanagh41
Estimated H-index: 41
Experiments were performed in chickens to ascertain whether application of infectious bronchitis (IB) H120 vaccine had an effect on the replication of an attenuated avian pneumovirus (APV) strain, using as indicators virus detection, humoral antibody responses and clinical protection against in vivo APV challenge. A preliminary experiment demonstrated that pharyngeal swabs were as efficient for recovery of APV as were buccal cavity swabs, and that either site was superior to swabbing the nasal c...
Published on Dec 1, 1999in Avian Pathology1.96
David Cavanagh41
Estimated H-index: 41
(Newbury College),
K. Mawditt12
Estimated H-index: 12
(Newbury College)
+ 1 AuthorsC. J. Naylor6
Estimated H-index: 6
(Newbury College)
In longitudinal studies, 13 flocks were swabbed twice each week for the life of the flock (up to 46 days). The swabs were analyzed by type-specific reverse transcriptase polymerase chain reactions. Massachusetts type vaccinal infectious bronchitis virus (IBVs), applied at the hatchery, were usually maximal during the first week, as expected and, notably, remained detectable for 3 to 4 weeks, occasionally longer. IBV of the 793/B type (also known as 4/91 and CR88) was detected in 11/13 flocks (85...
Published on Apr 1, 1999in Research in Veterinary Science1.75
R.S Khehra1
Estimated H-index: 1
(University of Liverpool),
R. C. Jones35
Estimated H-index: 35
(University of Liverpool)
Abstract One-day-old poults or two-week old chicks were infected oculonasally with avian pneumovirus. Cloacal swabs were collected for virus isolation as were selected tissues (Harderian gland, turbinates, trachea, lungs and kidneys) from birds killed at regular intervals up to 33 days post infection (p.i.) for poults, and up to 40 days p.i. for chicks. In an attempt to induce virus re-excretion, the T-cell-suppressor cyclosporin A ( CSA ) was given for 12 days starting from three weeks p.i. in ...
Published on Oct 1, 1997in Avian Diseases1.31
C. J. Naylor17
Estimated H-index: 17
,
K. J. Worthington10
Estimated H-index: 10
,
R. C. Jones35
Estimated H-index: 35
SUMMARY. Groups of turkey poults with high levels of maternal antibodies (MA+) to turkey rhinotracheitis virus (TRTV) were challenged with virulent TRTV at 1, 5, and 10 days of age. A maternal antibody-free group (MA-) was also challenged at 1 day of age. Before each challenge, levels of maternal antibodies to TRTV were measured by enzymelinked immunosorbent assay. Clinical signs were scored for each group. Unchallenged poults showed no signs. Respiratory signs in poults infected at 10 days of a...
Published on Dec 1, 1996in Avian Pathology1.96
R. C. Jones35
Estimated H-index: 35
(University of Liverpool)
Cited By9
Newest
Published on Nov 1, 2018in Veterinary Microbiology2.79
Christopher Ball2
Estimated H-index: 2
(University of Liverpool),
Anne Forrester6
Estimated H-index: 6
(University of Liverpool),
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool)
Abstract Respiratory diseases continue to have a major impact on poultry health, welfare and productivity. However, little information is available on their current status in UK poultry flocks. We investigated the presence of four economically important respiratory pathogens in healthy or problematic flocks; infectious bronchitis virus (IBV), avian metapneumovirus (aMPV), Mycoplasma gallisepticum (Mg) and Mycoplasma synoviae (Ms). Samples from 131 UK poultry flocks were received during the 12 mo...
Published on Dec 1, 2016in Worlds Poultry Science Journal1.36
S. Umar1
Estimated H-index: 1
,
H. Sabir1
Estimated H-index: 1
+ 1 AuthorsS. Subhan1
Estimated H-index: 1
Published on Jan 1, 2016in Methods of Molecular Biology
Yu Zhang9
Estimated H-index: 9
(OSU: Ohio State University),
Jing Sun5
Estimated H-index: 5
(OSU: Ohio State University)
+ 1 AuthorsJianrong Li23
Estimated H-index: 23
(OSU: Ohio State University)
Published on Nov 1, 2014in Journal of Virology4.32
Jing Sun5
Estimated H-index: 5
(OSU: Ohio State University),
Yongwei Wei9
Estimated H-index: 9
(OSU: Ohio State University)
+ 9 AuthorsXingmeng Lu2
Estimated H-index: 2
(ZJU: Zhejiang University)
Avian metapneumovirus (aMPV), also known as avian pneumovirus or turkey rhinotracheitis virus, is the causative agent of turkey rhinotracheitis and is associated with swollen head syndrome in chickens. Since its discovery in the 1970s, aMPV has been recognized as an economically important pathogen in the poultry industry worldwide. The conserved region VI (CR VI) of the large (L) polymerase proteins of paramyxoviruses catalyzes methyltransferase (MTase) activities that typically methylate viral ...
Published on Jan 1, 2014in Italian Journal of Animal Science1.26
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool),
E. Catelli12
Estimated H-index: 12
(UNIBO: University of Bologna)
+ 2 AuthorsR. C. Jones35
Estimated H-index: 35
(University of Liverpool)
This paper examines the effects on specific pathogen-free (SPF) chicks when avian metapneumovirus (aMPV) and Newcastle disease virus (NDV) La Sota strain vaccines are co-administered. Day-old SPF chicks were divided into five groups. The first group was inoculated with sterile water (SW) and the rest of the groups were inoculated with live NDV vaccine VG/GA by the oculo-oral route. At 21 days-old, the unvaccinated chicks were again inoculated with SW. The four VG/GA-vaccinated groups were furthe...
Published on Dec 1, 2012in Pesquisa Veterinaria Brasileira0.30
Márcia Bianchi dos Santos3
Estimated H-index: 3
(State University of Campinas),
Matheus C. Martini4
Estimated H-index: 4
(State University of Campinas)
+ 4 AuthorsClarice Weis Arns16
Estimated H-index: 16
(State University of Campinas)
Avian metapneumovirus (aMPV) is a respiratory pathogen associated with the swollen head syndrome (SHS) in chickens. In Brazil, live aMPV vaccines are currently used, but subtypes A and, mainly subtype B (aMPV/A and aMPV/B) are still circulating. This study was conducted to characterize two Brazilian aMPV isolates (A and B subtypes) of chicken origin. A challenge trial to explore the replication ability of the Brazilian subtypes A and B in chickens was performed. Subsequently, virological protect...
Published on Mar 1, 2011in Avian Diseases1.31
Jorge Luis Chacón10
Estimated H-index: 10
(USP: University of São Paulo),
Matheus Y. Mizuma2
Estimated H-index: 2
(USP: University of São Paulo)
+ 5 AuthorsAntonio José Piantino Ferreira16
Estimated H-index: 16
(USP: University of São Paulo)
SUMMARY. Avian metapneumovirus (AMPV) causes turkey rhinotracheitis and is associated with swollen head syndrome in chickens, which is usually accompanied by secondary infections that increase mortality. AMPVs circulating in Brazilian vaccinated and nonvaccinated commercial chicken and turkey farms were detected using a universal reverse transcriptase (RT)-PCR assay that can detect the four recognized subtypes of AMPV. The AMPV status of 228 farms with respiratory and reproductive disturbances w...
Published on May 1, 2010in Vaccine3.27
Kannan Ganapathy12
Estimated H-index: 12
(University of Liverpool),
Andrew Bufton1
Estimated H-index: 1
(Merial)
+ 2 AuthorsR. C. Jones35
Estimated H-index: 35
(University of Liverpool)
Abstract Avian metapneumovirus (aMPV) has become an important cause of viral respiratory infections in turkey and chickens. Live and inactivated vaccinations are available worldwide for prevention of disease and economic losses caused by this pathogen. The efficacy of these vaccines is vigorously tested under laboratory conditions prior to use in the field. In this study, a live subtype B aMPV vaccine was administered by spray, drinking water or oculo-oral methods to separate groups of broiler c...
Published on Dec 1, 2009in Avian Pathology1.96
Dennis Rubbenstroth16
Estimated H-index: 16
,
Silke Rautenschlein20
Estimated H-index: 20
The avian metapneumovirus (aMPV) is the causative agent of an acute respiratory disease in turkeys, which causes considerable economic losses to the poultry industry. Currently attenuated live and inactivated vaccines are widely used to control the disease, but vaccine breaks are frequently observed. For improvement of current vaccination strategies it is necessary to gain enhanced knowledge of the immune mechanisms against aMPV infection. Field observations suggest that vaccine-induced aMPV-spe...