Depletion of fat-resident Treg cells prevents age-associated insulin resistance
Abstract
Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically distinct forms of adult-onset diabetes. While macrophage-driven inflammation is a core driver of obesity-associated IR, the underlying mechanisms of the obesity-independent yet highly prevalent age-associated IR are largely unexplored. Here we show, using comparative adipo-immune profiling in mice, that fat-resident regulatory T cells, termed fTreg cells,...
Paper Details
Title
Depletion of fat-resident Treg cells prevents age-associated insulin resistance
Published Date
Nov 18, 2015
Journal
Volume
528
Issue
7580
Pages
137 - 141
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Notes
History