Contact dermatitis in the construction industry: the role of filaggrin loss-of-function mutations

A high prevalence of contact dermatitis (CD) and respiratory symptoms has been observed in the construction industry, probably due to widespread exposure to irritants and allergens. It is unknown whether carriers of loss-of-function mutations in the gene encoding filaggrin (FLG), a known risk gene for eczema and asthma, are at increased risk.To investigate associations of FLG mutations with CD and respiratory symptoms in Dutch construction...