Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
Abstract
Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like (TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9), have provided researchers with the ability to manipulate nearly any genomic sequence in human cells and model organisms. However, realizing the full potential of these genome-modifying technologies requires their safe...
Paper Details
Title
Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
Published Date
Nov 1, 2015
Journal
Volume
10
Issue
11
Pages
1842 - 1859
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