Simulated Annealing in Crystallography

X-ray crystallography (see Refs. 1 , 2 for reviews) is an increasingly impor­ tant tool for understanding structure, function, and control of biological macromolecules. Developments in genetics, data collection, and computer hardware have produced an unprecedented growth of macromolecular crystallographic studies. X-ray crystallography produces large amounts of diffraction data, whose interpretation is entirely dependent upon the availability of...