NRF2 regulates serine biosynthesis in non–small cell lung cancer

Lewis Cantley and colleagues report an integrated metabolic and transcriptomic study of non–small cell lung cancer (NSCLC) cell lines. They show that the activity of the serine/glycine biosynthetic pathway in NSCLC is highly heterogeneous and is regulated by NRF2 and that elevated expression of genes in this pathway confers poor prognosis in human NSCLC. Tumors have high energetic and anabolic needs for rapid cell growth and proliferation1, and...