Altering Tropism of rAAV by Directed Evolution

Pages: 151 - 173
Published: Jan 1, 2016
Abstract
Directed evolution represents an attractive approach to derive AAV capsid variants capable of selectively infect specific tissue or cell targets. It involves the generation of an initial library of high complexity followed by cycles of selection during which the library is progressively enriched for target-specific variants. Each selection cycle consists of the following: reconstitution of complete AAV genomes within plasmid molecules;...
Paper Details
Title
Altering Tropism of rAAV by Directed Evolution
Published Date
Jan 1, 2016
Pages
151 - 173
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