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Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia.
Abstract
Background Mast cell leukemia (MCL) is rare type of neoplasia with an incidence of 1% in a large series of 342 adult patients with systemic mastocytosis (SM). Chronic basophilic leukemia (CBL) is an extremely rare type of leukemia with appearance of 7 cases in the literature.
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  • References (23)
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Animesh D Pardanani74
Estimated H-index: 74
(Mayo Clinic)
Disease Overview: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extra-cutaneous organs. Diagnosis: The major criterion is presence of multifocal clusters of morphologically abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC expression of CD25 and/or CD2, and presence of KITD816V. Risk Stratification: The prognostic relevance of the 2008 World Health Organization (WHO) classificat...
55 Citations Source Cite
Animesh D Pardanani74
Estimated H-index: 74
(Mayo Clinic)
Disease overview: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extracutaneous organs. Diagnosis: The major criterion is presence of multifocal clusters of morphologically abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC expression of CD25 and/or CD2, and presence of KITD816V. Risk stratification: The 2008 World Health Organization (WHO) classification of SM has been shown to b...
51 Citations Source Cite
2005 in Clinical ImmunologyIF: 3.56
Knut Brockow7
Estimated H-index: 7
(National Institutes of Health),
Cem Akin46
Estimated H-index: 46
(National Institutes of Health)
+ 1 AuthorsDean D. Metcalfe89
Estimated H-index: 89
(National Institutes of Health)
Mastocytosis is often associated with organ involvement and hematological disorders. Patients may also exhibit elevated levels of plasma IL-6. To gain insight into the relevance of this observation, we correlated plasma levels of IL-6 and soluble IL-6 receptor (sIL-6R) with multiple disease parameters in 29 patients with mastocytosis. Mean plasma IL-6 levels were elevated in patients compared to healthy controls (P < 0.0001). Disease category significantly correlated with plasma IL-6 levels, as ...
37 Citations Source Cite
2003 in Experimental HematologyIF: 2.44
Cem Akin46
Estimated H-index: 46
(National Institutes of Health),
Knut Brockow7
Estimated H-index: 7
(National Institutes of Health)
+ 4 AuthorsDean D. Metcalfe89
Estimated H-index: 89
(National Institutes of Health)
Abstract Objective. STI571 is a tyrosine kinase inhibitor which inhibits the kinase activity of kit, the receptor for stem cell factor (SCF). Because activating mutations of c-kit affecting codon 816 are associated with human mast cell neoplasms, we determined whether STI571 exerted a similar cytotoxic effect on neoplastic and normal human mast cells. Methods. We investigated the effect of addition of STI571 in increasing concentrations (0.01 to 10 micromolar) to two HMC-1 human mast cell leukem...
180 Citations Source Cite
Katerina Panteli3
Estimated H-index: 3
,
Eleftheria Hatzimichael27
Estimated H-index: 27
(St Bartholomew's Hospital)
+ 4 AuthorsKonstantinos L. Bourantas19
Estimated H-index: 19
Summary A number of growth factors are involved in clonal haematopoietic expansion and their clinical significance in patients with chronic myeloproliferative diseases requires further evaluation. Using enzyme-linked immunosorbent assays, we analysed serum levels of interleukin (IL)-1a, IL-1b, IL-2, IL-6, the soluble IL-2 receptor alpha (sIL-2Ra), and thrombopoietin (TPO), in 25 individuals with myelofibrosis with myeloid metaplasia (MMM), 40 with essential thrombocythaemia (ET), eight with poly...
79 Citations Source Cite
2004 in AnaesthesiaIF: 5.43
V. Payne2
Estimated H-index: 2
,
P. C. A. Kam35
Estimated H-index: 35
(University of New South Wales)
Summary Mast cells, which are granulocytes found in peripheral tissue, play a central role in inflammatory and immediate allergic reactions. β-Tryptase is a neutral serine protease and is the most abundant mediator stored in mast cell granules. The release of β-tryptase from the secretory granules is a characteristic feature of mast cell degranulation. While its biological function has not been fully clarified, mast cell β-tryptase has an important role in inflammation and serves as a marker of ...
164 Citations Source Cite
2009 in Human PathologyIF: 3.13
Guilin Tang16
Estimated H-index: 16
(University of Massachusetts Amherst),
Lesley J. Woods1
Estimated H-index: 1
(University of Massachusetts Medical School)
+ 6 AuthorsSuyang Hao9
Estimated H-index: 9
(University of Massachusetts Amherst)
Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Con...
9 Citations Source Cite
2013 in BloodIF: 15.13
Sophie Georgin-Lavialle10
Estimated H-index: 10
(Necker-Enfants Malades Hospital),
Ludovic Lhermitte13
Estimated H-index: 13
(Paris Descartes University)
+ 3 AuthorsGandhi Damaj1
Estimated H-index: 1
(Paris Descartes University)
Mast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting for < 1% of all mastocytosis. It may appear de novo or secondary to previous mastocytosis and shares more clinicopathologic aspects with systemic mastocytosis than with acute myeloid leukemia. Symptoms of mast cell activation—involvement of the liver, spleen, peritoneum, bones, and marrow—are frequent. Diagnosis is based on the presence of ≥ 20% atypical mast cells in the marrow or ≥ 10% in the blood; how...
77 Citations Download PDF Cite
1991 in Brain ResearchIF: 3.13
Charles A. Dinarello170
Estimated H-index: 170
(Tufts University),
Joseph G. Cannon47
Estimated H-index: 47
(Tufts University)
+ 3 AuthorsFlavio Coceani28
Estimated H-index: 28
Abstract Fever induced by endogenous as well as exogenous pyrogens is often prevented by cyclooxygenase inhibitors; endogenous pyrogens stimulate prostaglandin E 2 (PGE 2 ) in or near the thermoregulatory centers of the brain. The cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), are two pyrogens which stimulate brain PGE 2 formation during fever and also increase PGE 2 synthesis in human mononuclear cells in vitro. In the present study, we examined whether interleukin-6 (IL-6) st...
141 Citations Source Cite
  • References (23)
  • Cited By (2)
2017 in Veterinary QuarterlyIF: 1.49
Estelle Rousselet1
Estimated H-index: 1
(University of Florida),
Terry M. Norton + 2 AuthorsNicole I. Stacy6
Estimated H-index: 6
(University of Florida)
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