Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
Abstract
Increasing evidence indicates that active DNA demethylation is involved in several processes in mammals, resulting in developmental stage-specificity and cell lineage-specificity. The recently discovered Ten-Eleven Translocation (TET) dioxygenases are accepted to be involved in DNA demethylation by initiating 5-mC oxidation. Aberrant DNA methylation profiles are associated with many diseases. For example in cancer, hypermethylation results in...
Paper Details
Title
Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
Published Date
Nov 3, 2013
Journal
Volume
42
Issue
3
Pages
1563 - 1574
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