Match!

ORIGINAL RESEARCH—PEYRONIE'S DISEASE Use of Penile Extender Device in the Treatment of Penile Curvature as a Result of Peyronie's Disease. Results of a Phase II Prospective Study

Published on Feb 1, 2009in The Journal of Sexual Medicine3.65
· DOI :10.1111/j.1743-6109.2008.01108.x
P. Gontero8
Estimated H-index: 8
(UNITO: University of Turin),
Massimiliano Di Marco3
Estimated H-index: 3
+ 4 AuthorsNicola Mondaini27
Estimated H-index: 27
(UniFI: University of Florence)
Cite
Abstract
Introduction. Pilot experiences have suggested that tension forces exerted by a penile extender may reduce penile curvature as a result of Peyronie's disease. Aim. To test this hypothesis in a Phase II study using a commonly marketed brand of penile extender. Methods. Peyronie's disease patients with a curvature not exceeding 50° with mild or no erectile dysfunction (ED) were eligible. Fifteen patients were required to test the efficacy of the device assuming an effect size of >0.8, consistent with an "important" reduction in penile curvature. Changes in penile length over baseline and erectile function (EF) domain scores of the International Index of Erectile Function (IIEF) constituted secondary end points. Main Outcome Measures. Patients were counselled on the use of the penile extender for at least 5 hours per day for 6 months. Photographic pictures of the erect penis and measurements were carried out at baseline, at 1, 3, 6, and 12 months (end of study). The IIEF-EF domain scores were administered at baseline and at the end of study. Treatment satisfaction was assessed at end of study using a nonvalidated institutional 5-item questionnaire. Results. Penile curvature decreased from an average of 31° to 27° at 6 months without reaching the effect size (P = 0.056). Mean stretched and flaccid penile length increased by 1.3 and 0.83 cm, respectively at 6 months. Results were maintained at 12 months. Overall treatment results were subjectively scored as acceptable in spite of curvature improvements, which varied from "no change" to "mild improvement." Conclusions. In our study, the use of a penile extender device provided only minimal improvements in penile curvature but a reasonable level of patient satisfaction, probably attributable to increased penile length. The selection of patients with a stabilized disease, a penile curvature not exceeding 50°, and no severe ED may have led to outcomes underestimating the potential efficacy of the treatment. Gontero P, Di Marco M, Giubilei G, Bartoletti R, Pappagallo G, Tizzani A, and Mondaini N. Use of penile extender device in the treatment of penile curvature as a result of Peyronie's disease. Results of a phase II prospective study. J Sex Med 2009;6:558- 566.
  • References (37)
  • Citations (84)
Cite
References37
Newest
#1E. Austoni (University of Milan)H-Index: 1
#2A. Guarneri (University of Milan)H-Index: 1
Last.G. Gatti (University of Milan)H-Index: 1
view all 3 authors...
#1James F. Smith (UCSF: University of California, San Francisco)H-Index: 26
#2Thomas J. Walsh (UCSF: University of California, San Francisco)H-Index: 15
Last.Tom F. Lue (UCSF: University of California, San Francisco)H-Index: 78
view all 5 authors...
#1Laurence A. Levine (Rush University Medical Center)H-Index: 50
#2Mark NewellH-Index: 2
Last.Frederick L. Taylor (Rush University Medical Center)H-Index: 7
view all 3 authors...
#1Anthony J Bella (U of O: University of Ottawa)H-Index: 24
#2Michael A. Perelman (Cornell University)H-Index: 25
Last.Tom F. Lue (UCSF: University of California, San Francisco)H-Index: 78
view all 4 authors...
#1Shane Russell (NU: Northwestern University)H-Index: 3
#2William D. Steers (Department of Urology, University of Virginia)H-Index: 53
Last.Kevin T. McVary (NU: Northwestern University)H-Index: 51
view all 3 authors...
#1Michael Ohebshalom (Cornell University)H-Index: 9
#2John P. Mulhall (Cornell University)H-Index: 54
Last.Marilyn Parker (Loyola University Medical Center)H-Index: 22
view all 4 authors...
Cited By84
Newest
#1Kiran L. Sharma (Mayo Clinic)
#2Manaf Alom (Mayo Clinic)H-Index: 3
Last.Landon Trost (Mayo Clinic)H-Index: 14
view all 3 authors...
#1Matthew G. Cowper (Tulane University)
#2Connor B. Burkett (Tulane University)
Last.Wayne J.G. Hellstrom (Tulane University)H-Index: 61
view all 5 authors...
#1Scott C. Brimley (Tulane University)H-Index: 1
#2Faysal A. Yafi (UCI: University of California, Irvine)H-Index: 14
Last.Georgios Hatzichristodoulou (University of Würzburg)H-Index: 10
view all 6 authors...
#1Peter Tsambarlis (Rush University Medical Center)H-Index: 3
#2Laurence A. Levine (Rush University Medical Center)H-Index: 50
View next paperPenile traction therapy for treatment of Peyronie's disease: a single-center pilot study.