Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis

Objective— The formation of neutrophil extracellular traps and the exposure of nucleosomes on these neutrophil extracellular traps contribute to coagulation activation and the propagation of deep vein thrombosis (DVT) in animal models. However, no data are available on the role of neutrophil extracellular traps or nucleosomes in patients with thrombosis. Methods and Results— We conducted a case–control study, in which levels of circulating...