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Salivary Testosterone Is Consistently and Positively Associated with Extraversion: Results from The Netherlands Study of Depression and Anxiety

Published on Jan 1, 2015in Neuropsychobiology1.675
· DOI :10.1159/000369024
Maureen M. J. Smeets-Janssen1
Estimated H-index: 1
,
Karin Roelofs33
Estimated H-index: 33
(Radboud University Nijmegen)
+ 4 AuthorsErik J. Giltay52
Estimated H-index: 52
(LEI: Leiden University)
Abstract
Background: Testosterone has been postulated as a ‘social' hormone, but the relationship between testosterone and personality traits linked with socially oriented
  • References (48)
  • Citations (12)
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References48
Newest
#1Dorien Enter (LEI: Leiden University)H-Index: 8
#2Philip Spinhoven (LEI: Leiden University)H-Index: 70
Last. Karin Roelofs (Radboud University Nijmegen)H-Index: 33
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Testosterone is an important regulator of social-motivational behavior and is known for its dominance-enhancing and social-anxiolytic properties. However, to date no studies have systematically investigated the causal effect of testosterone on actual social approach-avoidance behavior in humans. The present study sets out to test the effects of testosterone administration in healthy female volunteers using an objective implicit measure of social motivational behavior: the social Approach-Avoidan...
42 CitationsSource
#1Justin M. Johnson (Harvard University)H-Index: 4
#2Lisa B. Nachtigall (Harvard University)H-Index: 21
Last. Theodore A. Stern (Harvard University)H-Index: 32
view all 3 authors...
Background The effects of both high and low levels of testosterone are wide ranging and can include changes in mood, often overlapping with symptoms of mood disorders. Objective We sought to review the literature on the correlation of high and low levels of testosterone on mood disorders in men. Results Based on limited studies, high levels of testosterone are related to increased rates of depression as well as hypomania, whereas low levels of testosterone are related to depressive disorders in ...
27 CitationsSource
#1David A. Edwards (Emory University)H-Index: 36
#2Kathleen V. Casto (Emory University)H-Index: 6
article i nfo Recent research suggests that testosterone and cortisol jointly regulate dominance motivation and, perhaps, the status relationships that are affected by it. For this article, the results of six different studies of women's intercollegiate athletic competition were combined to give a sample size of almost ninety women for whom we had before- and after-competition values for salivary cortisol and testosterone for at least one and some- times two competitions. For many of these women...
50 CitationsSource
#1Philip Spinhoven (LEI: Leiden University)H-Index: 70
#2Mark de Rooij (LEI: Leiden University)H-Index: 17
Last. Brenda W.J.H. Penninx (LUMC: Leiden University Medical Center)H-Index: 134
view all 5 authors...
This prospective study examined the prognostic value of the Big Five personality model for changes in comorbidity patterns of emotional disorders both from a person- and trait-centered perspective. Moreover, it is investigated whether the predictive effect of personality can be attributed to symptom severity at baseline. We followed a cohort of 2566 persons (18-65 years) recruited in primary and specialized mental health care during two years. Personality dimensions at baseline were assessed wit...
9 CitationsSource
#1Peter Celec (Comenius University in Bratislava)H-Index: 28
#2Daniela Ostatníková (Comenius University in Bratislava)H-Index: 16
Abstract Background Saliva collection devices solve some of the technical issues related to sampling and processing of saliva. However, the widely used Salivette cotton or polypropylene rolls interfere with down-stream analysis of some of the salivary compounds. The aim of our study was to prove the effect of sampling using two different Salivette collection devices on salivary testosterone and estradiol concentrations. Methods Saliva samples were collected from young healthy women (n = 231) and...
15 CitationsSource
#1Luke D. Smillie (University of Melbourne)H-Index: 21
#2Andrew Cooper (Goldsmiths, University of London)H-Index: 34
Last. William R Revelle (NU: Northwestern University)H-Index: 40
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One of the most robust observations in personality and emotion research is the finding that extraverts are happier than introverts. Some theorists have attributed this to differential reactivity of the brain reward system, which is central to many biologically inspired models of extraversion. This affective-reactivity hypothesis, which suggests that extraverts should be more susceptible to the induction of positive affect, has so far received very mixed empirical support. In this article, we con...
63 CitationsSource
#1David Terburg (UU: Utrecht University)H-Index: 19
#2Henk AartsH-Index: 49
Last. Jack van HonkH-Index: 57
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Throughout vertebrate phylogeny, testosterone has motivated animals to obtain and maintain social dominance—a fact suggesting that unconscious primordial brain mechanisms are involved in social dominance. In humans, however, the prevailing view is that the neocortex is in control of primordial drives, and testosterone is thought to promote social dominance via conscious feelings of superiority, indefatigability, strength, and anger. Here we show that testosterone administration in humans prolong...
68 CitationsSource
#1Erik J. Giltay (LUMC: Leiden University Medical Center)H-Index: 52
#2Dorien Enter (LEI: Leiden University)H-Index: 8
Last. Karin Roelofs (LEI: Leiden University)H-Index: 33
view all 7 authors...
Abstract Objective Low circulating levels of testosterone have been associated with major depression, but there is more limited evidence for differences in patients with anxiety disorders. The use of selective serotonin reuptake inhibitors (SSRIs) and other antidepressants is associated with sexual side effects, warranting testing for interactions with testosterone. Methods Data are from 722 male and 1380 female participants of The Netherlands Study of Depression and Anxiety (NESDA), who were re...
71 CitationsSource
#1Jonas W. B. Lang (UM: Maastricht University)H-Index: 14
#2Ingo Zettler (University of Tübingen)H-Index: 23
Last. Ute R. Hülsheger (UM: Maastricht University)H-Index: 21
view all 4 authors...
Personality psychologists have long argued that explicit traits (as measured by questionnaires) channel the expression of implicit motives (as measured by coding imaginative verbal behavior) such that both interact in the prediction of relevant life outcome variables. In the present research, we apply these ideas in the context of industrial and organizational psychology and propose that 2 explicit traits work as channels for the expression of 3 core implicit motives in task and contextual job p...
31 CitationsSource
#1Richard B. SlatcherH-Index: 18
#2Pranjal H. Mehta (UO: University of Oregon)H-Index: 22
Last. Robert Josephs (University of Texas at Austin)H-Index: 39
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In this study, 76 men came into the lab in pairs and engaged in a 7-minute videotaped mate competition for the attention of an attractive female confederate. Pre-competition testosterone (T) levels were positively associated with men’s dominance behaviors and with how much the confederate indicated that she “clicked” with each participant. Dyadic analyses showed that self-reported dominance moderated the effects of T on one’s own dominance behaviors and on opponents' dominance behaviors. Specifi...
47 CitationsSource
Cited By12
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#1Xianjie He (SUFE: Shanghai University of Finance and Economics)H-Index: 1
#2Huifang Yin (SUFE: Shanghai University of Finance and Economics)H-Index: 1
Last. Hailong Zhao (SWUFE: Southwestern University of Finance and Economics)H-Index: 1
view all 5 authors...
We use a large pictorial sample of Chinese financial analysts to test the association between facial width‐to‐height ratio (fWHR) and performance in men. Financial analysts offer an ideal setting for our investigation because we can objectively track individual analysts’ behaviors and performance. We find that high‐fWHR analysts are more likely to conduct corporate site visits and they exhibit better performance. The positive fWHR–performance association survives a battery of robustness checks a...
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#1Jennifer S. MascaroH-Index: 10
#2Kelly E. Rentscher (Semel Institute for Neuroscience and Human Behavior)H-Index: 4
Last. Matthias R. MehlH-Index: 33
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#1Jennifer Kurath (University of Basel)H-Index: 1
#2Rui Mata (University of Basel)H-Index: 20
Abstract Hormonal levels have been hypothesized to serve as proximal biological mechanisms underlying individual differences in risk taking. We conducted a systematic literature search and independent meta-analyses to assess the link between endogenous testosterone, estradiol, and cortisol levels and risk-taking related constructs (i.e., risk-taking propensity, impulsivity, sensation seeking, novelty seeking). We found small correlations between risk-taking constructs and testosterone (r = 0.12,...
3 CitationsSource
#1Hirokazu Doi (Nagasaki University)H-Index: 12
#2Ilaria Basadonne (University of Trento)H-Index: 2
Last. Kazuyuki Shinohara (Nagasaki University)H-Index: 24
view all 4 authors...
Abstract Music constitutes an integral part of everyday life. There is great variation in preference patterns for music. However, the cause of such individual differences has not been fully elucidated to date. Many behavioral traits, including personality, are known to be influenced by steroid-hormone testosterone. On this basis, we conjectured that testosterone partly determines individual differences in music preference. To examine this hypothesis, in the present study, we investigated the ass...
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#1A. E. de Wit (UG: University of Groningen)H-Index: 1
#2Fokko J. Bosker (UG: University of Groningen)H-Index: 27
Last. Robert A. Schoevers (UG: University of Groningen)H-Index: 51
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Summary Testosterone is involved in many processes like aggression and mood disorders. As it may easily diffuse from blood into saliva, salivary testosterone is thought to reflect plasma free testosterone level. If so, it would provide a welcome noninvasive and less stressful alternative to blood sampling. Past research did not reveal consensus regarding the strength of the association, but sample sizes were small. This study aimed to analyse the association in a large cohort. In total, 2,048 pa...
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#1Dennis J.L.G. Schutter (Radboud University Nijmegen)H-Index: 37
#2Rosa Meuwese (LEI: Leiden University)H-Index: 6
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Previous research has found an association between a smaller cerebellar volume and higher levels of neuroticism. The steroid hormone testosterone reduces stress responses and the susceptibility to negative mood. Together with in vitro studies showing a positive effect of testosterone on cerebellar gray matter volumes, we set out to explore the role of testosterone in the relation between cerebellar gray matter and neuroticism. Structural magnetic resonance imaging scans were acquired, and indice...
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#2Huifang YinH-Index: 1
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#1Alessandra D. Nostro (HHU: University of Düsseldorf)H-Index: 2
#2Veronika I. Müller (HHU: University of Düsseldorf)H-Index: 16
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
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Previous studies have shown that males and females differ in personality and gender differences have also been reported in brain structure. However, effects of gender on this "personality-brain" relationship are yet unknown. We therefore investigated if the neural correlates of personality differ between males and females. Whole brain voxel-based morphometry was used to investigate the influence of gender on associations between NEO FFI personality traits and gray matter volume (GMV) in a matche...
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#1Henk R. Cremers (U of C: University of Chicago)H-Index: 9
#2Karin Roelofs (Radboud University Nijmegen)H-Index: 33
Social anxiety is a common disorder characterized by a persistent and excessive fear of one or more social or performance situations. Behavioral inhibition is one of the early indicators of social anxiety, which later in life may advance into a certain personality structure (low extraversion and high neuroticism) and the development of maladaptive cognitive biases. While there are several effective psycho- and pharmacotherapy options, a large number of patients benefit insufficiently from these ...
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