Fast gapped-read alignment with Bowtie 2

Volume: 9, Issue: 4, Pages: 357 - 359
Published: Apr 1, 2012
Abstract
As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity...
Paper Details
Title
Fast gapped-read alignment with Bowtie 2
Published Date
Apr 1, 2012
Volume
9
Issue
4
Pages
357 - 359
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