κ chain monoallelic demethylation and the establishment of allelic exclusion
Abstract
Allelic exclusion in kappa light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional kappa light chain on the surface of the B cell leads to an intracellular signal that down-regulates the V(D)J recombinase, thus precluding rearrangement of the other allele. Whereas such a feedback mechanism clearly plays a role in the maintenance of allelic exclusion, here we provide evidence suggesting that...
Paper Details
Title
κ chain monoallelic demethylation and the establishment of allelic exclusion
Published Date
Jun 15, 1998
Journal
Volume
12
Issue
12
Pages
1801 - 1811
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