Cetirizine release from cyclodextrin formulated compressed chewing gum

Beside the efficient effect on masking cetirizine bitter taste, the cyclodextrins (CDs) as well could have influence on the release from the formulation. In vitro release profiles of cetirizine from compressed chewing gums containing α-, β- and γ-CD were investigated using a three cell chewing apparatus. Different cetirizine/CD formulations were produced and analysed with respect to type of CD (α-, β- and γ-CD), the molar ratio between...