Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses
Abstract
Summary: Encouraging efficacy data have been obtained in the hepatitis C virus (HCV) chimpanzee model using prophylactic vaccines comprising adjuvanted recombinant envelope gpE1/gpE2 glycoproteins or prime/boost immunization regimens using defective adenoviruses and plasmid DNA expressing non-structural genes. While usually not resulting in sterilizing immunity after experimental challenge, the progression to chronic, persistent infection (which...
Paper Details
Title
Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses
Published Date
Dec 28, 2010
Journal
Volume
239
Issue
1
Pages
99 - 108
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