Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin
Abstract
Oral insulin delivery is often limited by protease degradation. 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate (Camostat mesylate) is reported to have the ability to inhibit trypsin activity, which is the main protease responsible for protein degradation. This study attempted to form a novel nanoparticle by covalently conjugating 4-(2-(2-aminoethylamino)-2-oxoethyl)phenyl 4-guanidinobenzoyloxy (FOY-251), an...
Paper Details
Title
Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin
Published Date
Sep 24, 2015
Volume
32
Issue
7
Pages
632 - 641
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