Inhibition of LPS-induced Cytokines by Bcl-xL in a Murine Macrophage Cell Line
Abstract
The antiapoptotic molecule Bcl-xL has been implicated in the differentiation and survival of activated macrophages in inflammatory conditions. In this report, the role of Bcl-xL in LPS-induced cytokine gene expression and secretion was studied. Bcl-xL-transfected RAW 264 macrophages were protected from gliotoxin-induced apoptosis, indicating the presence of functional Bcl-xL. Overexpression of Bcl-xL in this macrophage cell line was also...
Paper Details
Title
Inhibition of LPS-induced Cytokines by Bcl-xL in a Murine Macrophage Cell Line
Published Date
Sep 1, 2000
Journal
Volume
165
Issue
5
Pages
2729 - 2737
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