Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
Abstract
The alternative non-homologous end-joining (NHEJ) machinery facilitates several genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fusions. Using next-generation sequencing technology, here we show that repair by alternative NHEJ yields non-TTAGGG nucleotide insertions at fusion...
Paper Details
Title
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
Published Date
Feb 2, 2015
Journal
Volume
518
Issue
7538
Pages
254 - 257
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