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Published on Feb 1, 2008in Biological Psychiatry 11.50
Christine Heim54
Estimated H-index: 54
(Emory University),
Tanja Mletzko11
Estimated H-index: 11
(Emory University)
+ 2 AuthorsCharles B. Nemeroff131
Estimated H-index: 131
(Emory University)
Background The dexamethasone/corticotropin-releasing factor (CRF) test is considered to be the most sensitive measure of hypothalamic–pituitary–adrenal (HPA) axis hyperactivity and has been demonstrated to be altered in patients with major depression (MDD). Although childhood trauma is a demonstrated risk factor for MDD and patients with a history of childhood abuse and MDD demonstrate HPA axis hyperactivity, the dexamethasone/CRF test remains unstudied in this population. We determined the impa...
240 Citations Source Cite
Published on Feb 1, 2008in British Journal of Psychiatry 7.23
James H. Cole20
Estimated H-index: 20
P. M C Guffin104
Estimated H-index: 104
Anne Farmer67
Estimated H-index: 67
Recent developments in the classification of major depressive disorder are reviewed in light of the predictions made by Kendell in the 1970s. Particularly, the institution of operational diagnoses along with the contentious issues of subdividing major depressive disorder and its characterisation on a dimensional as opposed to a categorical scale.
26 Citations Source Cite
Published on Feb 1, 2008in Archives of General Psychiatry
Rebekah Bradley17
Estimated H-index: 17
(Emory University),
Elisabeth B. Binder32
Estimated H-index: 32
(Emory University)
+ 13 AuthorsD. Jeffrey Newport40
Estimated H-index: 40
(Emory University)
Context Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene × environment interaction at this locus may be important in depression. Objective To examine whether the effects of child abuse on adult depressive symptoms are moderated by genetic polymorphisms within the corticotropin-releasi...
476 Citations Source Cite
Published on Dec 1, 2007in Journal of Affective Disorders 4.08
Sergi Papiol24
Estimated H-index: 24
(University of Barcelona),
Bárbara Arias22
Estimated H-index: 22
(University of Barcelona)
+ 3 AuthorsLourdes Fañanás34
Estimated H-index: 34
(University of Barcelona)
Abstract Background Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been observed in major depression. Normalization of HPA axis has been suggested to play a role in the mechanisms of action of antidepressants. Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment. Methods The sample consisted of 159 depressive outpatients and 96 healthy controls...
127 Citations Source Cite
Published on Aug 1, 2007in European Child & Adolescent Psychiatry 3.74
Abiodun O. Adewuya27
Estimated H-index: 27
(OAU: Obafemi Awolowo University),
Bola A. Ola18
Estimated H-index: 18
(OAU: Obafemi Awolowo University),
Olutayo O. Aloba11
Estimated H-index: 11
(OAU: Obafemi Awolowo University)
Aim The aims of this study are to estimate the prevalence of major depressive disorder (MDD) in a representative sample of Nigerian adolescents, and to assess the validity of Beck Depression Inventory (BDI) in screening for depressive symptoms among adolescent population in Nigeria.
48 Citations Source Cite
Published on May 1, 2007in European Journal of Cancer Care 2.42
Kyriaki Mystakidou34
Estimated H-index: 34
(UoA: National and Kapodistrian University of Athens),
Eleni Tsilika29
Estimated H-index: 29
(UoA: National and Kapodistrian University of Athens)
+ 3 AuthorsL. Vlahos19
Estimated H-index: 19
(UoA: National and Kapodistrian University of Athens)
To validate the Greek version of the Beck Depression Inventory (BDI)-21 items in advanced cancer patents attending a palliative care unit. The scale was translated with the forward–backward procedure into Greek. It was administered twice, with a 1-week interval, to 105 patients with advanced cancer. The patients also completed the Hospital Anxiety and Depression (HAD) scale, while researchers recorded data on demographic characteristics, disease status and treatment regimen. The Greek version of...
50 Citations Source Cite
Published on Apr 1, 2007in Archives of General Psychiatry
Jerome C. Wakefield35
Estimated H-index: 35
Mark F. Schmitz17
Estimated H-index: 17
+ 1 AuthorsAllan V. Horwitz36
Estimated H-index: 36
Context Symptoms of intense bereavement-related sadness may resemble those of major depressive disorder (MDD) but may not indicate a mental disorder. To avert false-positive diagnoses, DSM criteria for MDD exclude uncomplicated bereavement of brief duration and modest severity. However, the DSM does not similarly exempt depressive reactions to other losses, even when they are uncomplicated in duration and severity. Objective To test the validity of the DSM exclusion of uncomplicated depressive s...
158 Citations Source Cite
Published on Nov 1, 2006in Neuropsychopharmacology 7.16
Angelika Erhardt25
Estimated H-index: 25
(MPG: Max Planck Society),
Marcus Ising57
Estimated H-index: 57
(MPG: Max Planck Society)
+ 7 AuthorsMartin E. Keck37
Estimated H-index: 37
(MPG: Max Planck Society)
Regulation of the Hypothalamic–Pituitary–Adrenocortical System in Patients with Panic Disorder
68 Citations Source Cite
Published on Oct 1, 2006in Amino Acids 2.52
M. E. Keck1
Estimated H-index: 1
Affective disorders tend to be chronic and life-threatening diseases: suicide is estimated to be the cause of death in 10–15% of individuals with major depressive disorders. Major depression is one of the most prevalent and costly brain diseases with up to 20% of the worldwide population suffering from moderate to severe forms of the disease. Only 50% of individuals with depression show full remission in response to currently available antidepressant drug therapies which are based on serendipito...
72 Citations Source Cite
Published on Sep 1, 2006in Neuroscience Letters 2.17
Zhongchun Liu15
Estimated H-index: 15
(WHU: Wuhan University),
Fan Zhu9
Estimated H-index: 9
(WHU: Wuhan University)
+ 8 AuthorsZhijian Cao29
Estimated H-index: 29
(WHU: Wuhan University)
Abstract The dysregulation of the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis system is one of the major neuroendocrine abnormalities in major depression (MD). Many pieces of evidence supported that corticotropin-releasing hormone (CRH) play a role in the pathophysiology of major depression. In this article, whether genetic variations in the corticotropin-releasing hormone receptor1 (CRHR1) gene might be associated with increased susceptibility to major depression was studie...
113 Citations Source Cite
Cited By1
Published on Nov 1, 2010in Developmental Psychobiology 1.85
Aniko Korosi5
Estimated H-index: 5
(UCI: University of California, Irvine),
Tallie Z. Baram70
Estimated H-index: 70
(UCI: University of California, Irvine)
The concept that early-life experience influences the brain long-term has been extensively studied over the past 50 years, whereas genetic factors determine the sequence and levels of expression of specific neuronal genes, this genetic program can be modified enduringly as a result of experience taking place during critical developmental periods. This programming is of major importance because it appears to govern many behavioral and physiological phenotypes and promote susceptibility or resilie...
49 Citations Source Cite