The archaeal eIF2 homologue: functional properties of an ancient translation initiation factor
Abstract
The eukaryotic translation initiation factor 2 (eIF2) is pivotal for delivery of the initiator tRNA (tRNAi) to the ribosome. Here, we report the functional characterization of the archaeal homologue, a/eIF2. We have cloned the genes encoding the three subunits of a/eIF2 from the thermophilic archaeon Sulfolobus solfataricus, and have assayed the activities of the purified recombinant proteins in vitro. We demonstrate that the trimeric factor...
Paper Details
Title
The archaeal eIF2 homologue: functional properties of an ancient translation initiation factor
Published Date
Jan 1, 2005
Journal
Volume
33
Issue
6
Pages
1804 - 1812
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