Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due to PNPLA3 Sequence Variant
Volume: 100, Issue: 5, Pages: E821 - E825
Published: May 1, 2015
Abstract
Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic disease characterized by increased hepatic fat, due to an imbalance between synthesis and removal of hepatic lipids. In particular, increased hepatic de novo lipogenesis (DNL) is a key feature associated with NAFLD. The genetic variations I148M in PNPLA3 and E167K in TM6SF2 confer susceptibility to NAFLD.Here we aimed to investigate the contribution of DNL to liver fat accumulation...
Paper Details
Title
Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due to PNPLA3 Sequence Variant
Published Date
May 1, 2015
Volume
100
Issue
5
Pages
E821 - E825
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