Induction of cardiac autoimmunity in Chagas heart disease: A case for molecular mimicry
Abstract
Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy (CCC) up to 30 years after infection. Cardiomyocyte destruction is associated with a T cell-rich inflammatory infiltrate and fibrosis. The presence of such lesions in the relative scarcity of parasites in the heart, suggested that CCC might be due, in part, to a...
Paper Details
Title
Induction of cardiac autoimmunity in Chagas heart disease: A case for molecular mimicry
Published Date
Jan 1, 2006
Journal
Volume
39
Issue
1
Pages
41 - 54
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