Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study

Objective Central obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 ( GNPDA2 ), rs8050136 ( FTO ) and rs17782313 ( MC4R ), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether...